Figure 5. Head and neck squamous cell carcinoma immune infiltration and patient survival.

(A) Correlations between expression levels plotted above or below the median of CD8⁺ T cell infiltration, overall T cell infiltration score (TIS), overall immune cell infiltration score (IIS), and patient cumulative survival. (B) Correlations between patient cumulative survival and immune cell subpopulations and immune effector agents represented by the –log10 P value of the hazard ratio with more positive values indicating better survival and negative values indicating worse survival. (C) Correlation between expression levels plotted above or below the median of Treg infiltration and patient cumulative survival adjusted only for HPV status. Additional correlation between expression levels plotted above or below the median of Treg infiltration and patient cumulative survival adjusted for HPV status, CD8⁺ TIS, and CD56^dim NK cell infiltration, abrogating the survival advantage for Tregs alone. (D) Correlation between high and low expression levels of CD56^dim NK cell infiltration and patient cumulative survival adjusted for HPV status. P values for significance (<0.05) calculated using multivariable Cox regression analysis. n = 280.