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. Author manuscript; available in PMC: 2017 Oct 15.
Published in final edited form as: Dev Biol. 2016 Aug 27;418(2):242–247. doi: 10.1016/j.ydbio.2016.08.029

Figure 3. Perlecan knockdown significantly decreases the stiffness of the cells and ECM in developing articular cartilage.

Figure 3

A) High-resolution stiffness maps show an increase in stiffness with age and perlecan incorporation. Boxes indicate representative regions where cell (white) and ECM (black) stiffness were measured. B) Both cell and ECM stiffness are influenced by perlecan content (*p<0.0001). Two-way ANOVA analysis of ECM and cell stiffness reveals a significant effect of age (p<0.0001) and genotype (p<0.0001). The interaction between age and genotype was significant for both components of the tissue (p<0.01). Data for each time point were pooled from three independent litters in which all three genotypes were represented. Error bars = s.d.