Table 4.

Mean arterial blood pressure change (ΔMAP) during the cold pressor test for four ADRA1B variants.

SNP	Caucasians				African Americans				All
	ΔMAP, mmHg, Mean (95% CI)			P- value*	ΔMAP, mmHg, Mean (95% CI)			P- value*	P-value*
	Number of variant alleles				Number of variant alleles
	0	1	2		0	1	2
rs10070745	17 (14 – 20) n=36	n=0	n=0	NA	17 (11 – 23) n=13	22 (14 –30) n=8	n=0	0.008	NA
rs17057303	18 (14–21) n= 35	8 n=1	n=0	0.38	20 (15 – 25) n=18	11 (−4 – 26) n=3	n=0	0.12	0.050
rs952037	14 (10 – 18) n=20	22 (18 – 27) n =14	13 (−57 – 83) n=2	0.16	17 (12 – 22) n=5	19 (11 – 28) n=11	20 (13 – 28) n = 5	0.75	0.21
rs7737796	15 (9 – 21) n=12	17 (13 – 22) n=19	23 (16 – 30) n=5	0.13	19 (14 – 25) n=5	18 (12 – 24) n=13	22 (−23 – 67) n=3	0.47	0.078

^*P value adjusted for age, sex, BMI, baseline mean arterial pressure and ethnicity for analysis of the combined group.

NA=not assessed.