Table 1.
N=12 | |
---|---|
| |
Age (days) | 59 (0.0, 574) |
| |
Gestational age (weeks) | 39 (27, 39) |
| |
Weight (kg) | 3.7 (2.9, 9.6) |
| |
Birth weight (kg) | 3 (2.4, 4.3) |
| |
Male, n (%) | 5 (42) |
| |
Race, n (%) | |
White | 6 (50) |
African American | 6 (50) |
| |
Diagnosis, n (%) | |
Cardiomyopathy | 4 (34) |
Pulmonary hypertension | 3 (25) |
Congenital heart disease | 3 (25) |
Congenital diaphragmatic hernia | 1 (8) |
Respiratory failure | 1 (8) |
| |
Serum creatinine (mg/dL)† | 0.5 (0.2, 1.6) |
| |
ECMO support, n (%) | |
Veno-arterial | 11 (92) |
Veno-venous | 1 (8) |
| |
ECMO circuit configuration, n (%) | |
S3 | 8 (67) |
Cardiohelp | 4 (33) |
| |
Micafungin indication n (%) | |
Prophylaxis | 11 (92) |
Therapy | 1 (8) |
| |
Micafungin dosing (mg/kg/day) | 4 (4, 8) |
| |
Duration of therapy (days) | 4 (2, 8) |
| |
Duration of ECMO support at time of
first micafungin dosing (days) |
4 (2, 10) |
| |
Number of PK samples per infant | 11 (6, 14) |
| |
PK samples obtained around, n (%) | |
Dose 1-2 | 12 (100) |
Dose 4-5 | 6 (50) |
Results are expressed as median (range) unless otherwise specified
Median serum creatinine for each subject over the study period.