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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Osteoarthritis Cartilage. 2016 Jun 27;24(11):1989–1998. doi: 10.1016/j.joca.2016.06.014

Figure 4.

Figure 4

LIPUS regulates chondrocyte metabolism (n=3). A) IL-1β significantly increases MMP3 and ADAMTS5 mRNA expression in C-28/I2 cells. LIPUS stimulation significantly reduces IL-1β induced MMP13 and ADAMTS5 mRNA expression. B) LIPUS significantly increase Col II, aggrecan and COMP expression in chondrocytes and protects against IL-1 stimulation intensified collagen staining and represents significant difference between Ctrl and IL-1β, p=0.028, # significant difference between IL-1 and IL-1β, p=0.028, # LIPU and †nsignificant difference between Ctrl and LIPUS groups, p=0.028. Bars indicate group means and error bars show 95% confidence intervals.