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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Osteoarthritis Cartilage. 2016 Jun 27;24(11):1989–1998. doi: 10.1016/j.joca.2016.06.014

Figure 5.

Figure 5

LIPUS enhances C-28/I8 cells migration and proliferation (n=3) A) IL-1βIinhibits chondrocyte migration, LIPUS stimulation enhances chondrocyte migration into the empty region and suppresses IL-1β anti-migratory effects. B) Scratch area remains mostly cell-free in IL-1βacultures, LIPUS reverses the IL-1β effects as more than 90% of the area is covered in LIPUS treated cultures. C) ImageJ analysis shows significantly higher number of cells (> 500 cells) migrated into scratch area in LIPUS treated cultures in comparison to <50 cells migrated in IL-1β treated culture. D) Proliferation study shows no significant differences at D1 and D3 but LIPUS stimulated cultures show significant increase at D5. IL-1β cultures show no or little effect on chondrocyte proliferation. * represents significant difference between Ctrl and IL-1 representndroc significant difference between IL-1 and IL-1 representndrocyte pand †nsignificant difference between Ctrl and LIPUS groups, p=0.028. Bars indicate group means and error bars show 95% confidence intervals.