Table 1. Frequency, percent complete and percent incomplete by required site specific factors (SSF) and histology (SEER 2004-2012, varying).
| Variable | World Health Organization (WHO) grade classification |
Methylation of 06-methylguanine- methyltransferase (MGMT) |
Chromosome lp: loss of heterozygosity (LOH) |
Chromosome 19q: loss of heterozygosity (LOH) |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SSF | 1 | 4 | 5 | 6 | ||||||||
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| Histology | Total | Complete (%) |
Incomplete (%) |
Total | Complete (%) |
Incomplete (%) |
Total | Complete (%) |
Incomplete (%) |
Total | Complete (%) |
Incom- plete (%) |
| Pilocytic astrocytoma | 2291 | 64.1 | 35.9 | 796 | 1.1 | 98.9 | 796 | 1.5 | 98.5 | 796 | 1.4 | 98.6 |
| Diffuse astrocytoma | 3760 | 76.9 | 23.1 | 1141 | 5.7 | 94.3 | 1141 | 8.8 | 91.2 | 1141 | 8.9 | 91.1 |
| Anaplastic astrocytoma | 2724 | 86.5 | 13.5 | 1004 | 8.4 | 91.6 | 1004 | 15.3 | 84.7 | 1004 | 15.4 | 84.6 |
| Unique astrocytoma variants | 416 | 59.6 | 40.4 | 144 | 1.4 | 98.6 | 144 | 2.1 | 97.9 | 144 | 2.1 | 97.9 |
| Glioblastoma | 22,528 | 69.3 | 30.7 | 8083 | 12.2 | 87.8 | 8083 | 4.7 | 95.3 | 8083 | 4.7 | 95.3 |
| Oligodendroglioma | 1972 | 84.1 | 15.9 | 589 | 6.1 | 93.9 | 589 | 49.4 | 50.6 | 589 | 49.7 | 50.3 |
| Anaplastic oligodendroglioma | 883 | 87.3 | 12.7 | 290 | 8.6 | 91.4 | 290 | 43.4 | 56.6 | 290 | 43.1 | 56.9 |
| Oligoastrocytic tumors | 1506 | 87.9 | 12.1 | 515 | 9.5 | 90.5 | 515 | 47.8 | 52.2 | 515 | 49.3 | 50.7 |
| Ependymal tumors | 3002 | 49.5 | 50.5 | 1053 | 0.9 | 99.1 | 1053 | 0.3 | 99.7 | 1053 | 0.3 | 99.7 |
| Glioma malignant, NOS | 1059 | 40.2 | 59.8 | 361 | 2.8 | 97.2 | 361 | 6.4 | 93.6 | 361 | 6.4 | 93.6 |
| Choroid plexus tumors | 387 | 41.9 | 58.1 | – | – | – | – | – | – | – | – | – |
| Other neuro-epithelial tumors | 53 | 43.4 | 56.6 | 20 | 5.0 | 95.0 | 20 | 0.0 | 100.0 | 20 | 0.0 | 100.0 |
| Neuronal and mixed neuronal-glial tumors | 1703 | 52.4 | 47.6 | 118 | 0.8 | 99.2 | 118 | 7.6 | 92.4 | 118 | 7.6 | 92.4 |
| Embryonal tumors | 1825 | 49.9 | 50.1 | – | – | – | – | – | – | – | – | – |
| Medulloblastoma | 1058 | 57.3 | 42.7 | – | – | – | – | – | – | – | – | – |
| PNET | 365 | 43.8 | 56.2 | – | – | – | – | – | – | – | – | – |
| ATRT | 185 | 45.4 | 54.6 | – | – | – | – | – | – | – | – | – |
| All other embryonal | 217 | 28.1 | 71.9 | – | – | – | – | – | – | – | – | – |
| Nerve sheath tumors | 7811 | 11.6 | 88.4 | – | – | – | – | – | – | – | – | – |
| Meningioma | 28,058 | 52.3 | 47.7 | – | – | – | – | – | – | – | – | – |
| Mesenchymal tumors | 523 | 26.0 | 74.0 | – | – | – | – | – | – | – | – | – |
| Primary melanocytic lesions | 51 | 3.9 | 96.1 | – | – | – | – | – | – | – | – | – |
| Other neoplasms related to the meninges | 1371 | 24.7 | 75.3 | – | – | – | – | – | – | – | – | – |
| Germ cell tumors, cysts and heterotopias | 623 | 1.4 | 98.6 | – | – | – | – | – | – | – | – | – |
| Tumors of the pituitary | 15,409 | 1.5 | 98.5 | – | – | – | – | – | – | – | – | – |
| Craniopharyngioma | 1243 | 20.6 | 79.4 | – | – | – | – | – | – | – | – | – |
| Hemangioma | 869 | 2.2 | 97.8 | – | – | – | – | – | – | – | – | – |
| Neoplasm, unspecified | 720 | 5.7 | 94.3 | – | – | – | – | – | – | – | – | – |
| All other | 28 | 17.9 | 82.1 | – | – | – | – | – | – | – | – | – |
| Total | 101,116 | 46.5 | 53.5 | 14,115 | 9.0 | 91.0 | 14,115 | 9.5 | 90.5 | 14,115 | 9.6 | 90.4 |