Table 2.
Toxicities
| Type of toxicity | Grade 3, n (%) | Grade 4, n (%) | Grade 5, n (%) |
|---|---|---|---|
| Cardiovascular/pulmonary | |||
| DIC | 1 (3.0) | ||
| Dyspnea | 2 (6.0) | ||
| Hypertension | 1 (3.0) | ||
| Pleural effusion | 1 (3.0) | ||
| Pulmonary/upper respiratory—other | 1 (3.0) | ||
| Troponin 1 | 1 (3.0) | ||
| Gastrointestinal | |||
| Anorexia | 2 (6.0) | ||
| Nausea | 3 (9.0) | ||
| Vomiting | 2 (6.0) | ||
| Diarrhea | 1 (3.0) | ||
| Constitutional | |||
| Fatigue | 5 (15.2) | ||
| Neurologic | |||
| Confusion | 1 (3.0) | ||
| Encephalopathy | 1 (3.0) | ||
| Laboratory abnormalities | |||
| Alkaline phosphatase | 3 (9.0) | ||
| Anemia | 2 (6.0) | ||
| AST/ALT | 1 (3.0) | ||
| Bilirubin | 2 (6.0) | ||
| Hemoglobin | 1 (3.0) | ||
| Hyperglycemia | 4 (12.1) | ||
| Hypoalbuminemia | 2 (6.0) | ||
| Hyponatremia | 1 (3.0) | ||
| Leukocytes | 1 (3.0) | ||
| Lymphopenia | 2 (6.0) | ||
| Neutrophils | 1 (3.0) | ||
| Pain | |||
| Arthralgia/Myalgia | 2 (6.0) | ||
| Back Pain | 1 (3.0) | ||
| Headache | 1 (3.0) | ||
| Pelvic/Abdominal pain | 3 (9.0) | ||
| Other | |||
| Glaucoma | 1 (3.0) | ||
| Hypoxia | 1 (3.0) | ||
| Infection without neutropenia | 1 (3.0) | ||
| Sudden death | 1 (3.0) | ||