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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Biochim Biophys Acta. 2016 Sep 3;1864(12):1667–1677. doi: 10.1016/j.bbapap.2016.08.019

Fig. 7. Hierarchical clustering analysis of the HDX data for seven FXR-LBD-bound complexes.

Fig. 7

The peptide-level deuterium exchange-in level is color-coded from red to green indicating low (exchange-in protection) to high levels of exchange-in. “Counts” represents the pixels number (squares) of each color in the histogram based on the frequency of the pixels (squares) of each color in the heatmap. The heat map allows visualizing that the exchange-in dynamics observed for the prenylflavonoids is different from the exchange-in dynamics observed for FXR ligands with tetracyclic core skeletons. GW4064, a synthetic non-steroidal stilbene-based high affinity agonist, displays a unique FXR-LBD exchange-in dynamics different from that observed for the ligands with tetracyclic core and the prenylflavonoids.