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. 2016 Oct 20;10:201. doi: 10.3389/fnbeh.2016.00201

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Copyright © 2016 Liu, Zhang, Lin, Xia, Guo and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of chronic or acute exposure to VPA on thigmotaxis of zebrafish at 1 month of age. Distance moved in outer zone (%) in alternating 10-min blocks of light and dark. The control group (filled circles) was plotted with chronic exposure to 20 μM VPA (open circles) and acute exposure to 100 μM VPA (open circles) in (A,B), respectively. The shaded part in each panel represents the dark phase, and the non-shaded part in each panel represents the light phase. Average distance moved in the outer zone (%) during the 10-min dark phase was plotted in (C). The data are presented as the mean ± SEM, n = 32 animals per group. Statistical markers: ^*p < 0.05; significantly different from the controls.