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. 2016 Oct 20;9:104. doi: 10.3389/fnmol.2016.00104

FIGURE 2.

FIGURE 2

Structural modeling of Slitrk1, Slitrk2, and Slitrk4 residues that are mutated in human patients. Overall structures of LRR1 and LRR2 domains of human Slitrk1, Slitrk2 and Slitrk4 (left). The crystal structure of human Slitrk1 LRR1/human PTPδ Ig1-3 complex (PDB ID: 4RCA) and human Slitrk1 LRR2 (PDB ID: 4RCW) were used for presenting the structures of human Slitrk1 LRR1 and LRR2. The structure of human Slitrk2 and Slitrk4 were modeled with SWISS-MODEL server. The residues corresponding to patients’ mutations described in the current study are presented as red sticks in the cartoon presentation. Human Slitrk1, Slitrk2, and Slitrk4 are colored gray, cyan and purple, respectively. Yellow dotted regions in the LRR1 domains of Slitrks indicate the LAR-RPTP binding surfaces based on the 3D structure of the human Slitrk1 LRR1/PTPδ Ig1-3 complex (PDB ID: 4RCA), and black dotted lines represent flexible linkers between LRR1 and LRR2 domains (left). Close-up views of mutated and neighboring residues in LRR domains (right).