Table 2.
MICs and FICIs results with combinations of INK128 with antifungal agents against Fusarium spp.
| Strain | MICa (μg/ml) | FICIb | MICa (μg/ml) | FICIb | MICa (μg/ml) | FICIb | MICa (μg/ml) | FICIb | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| INK128 | ITC | INK128/ITC | VRC | INK128/VRC | POS | INK128/POS | AMB | INK128/AMB | |||||
| F. solani (1) | >16 | >16 | 4/8 | I | 8 | 2/2 | S | 4 | 2/4 | I | 4 | 8/4 | I |
| F. solani (2) | >16 | >16 | 4/8 | I | 4 | 2/2 | I | 4 | 2/2 | I | 2 | 8/2 | I |
| F. solani (3) | >16 | >16 | 4/4 | S | 8 | 2/2 | S | 4 | 4/2 | I | 4 | 8/4 | I |
| F. solani (4) | >16 | >16 | 4/8 | I | 8 | 1/2 | S | 4 | 8/4 | I | 4 | 8/4 | I |
| F. solani (5) | >16 | >16 | 4/16 | I | 8 | 2/4 | I | 4 | 2/1 | S | 2 | 4/2 | I |
| F. solani (6) | >16 | >16 | 8/16 | I | 8 | 2/2 | S | 4 | 2/4 | I | 4 | 4/2 | I |
| F. solani (7) | >16 | >16 | 4/4 | S | 8 | 2/1 | S | 8 | 2/2 | S | 2 | 8/2 | I |
| F. oxysporum (1) | >16 | >16 | 8/16 | I | 8 | 2/4 | I | 4 | 4/4 | I | 4 | 4/4 | I |
| F. oxysporum (2) | >16 | >16 | 8/16 | I | 8 | 2/4 | I | 8 | 2/2 | S | 4 | 4/4 | I |
| F. oxysporum (3) | >16 | >16 | 4/4 | S | 8 | 2/2 | S | 4 | 8/4 | I | 2 | 4/1 | I |
a
The MIC is the concentration achieving 100% growth inhibition.
b
S, synergy (FICI of ≤0.5); I, no interaction (indifference) (0.5 < FICI ≤4).