Table 2.
(A) Suggests that HLA class I and class II alleles are common genetic variants (>5%). (B) Suggests that KIR genes and KIR gene-content haplotypes are common genetic variants.
| Variables | p-value | Odds ratio | Subjects (%) | Controls (%) | Common variant (>5%) |
|---|---|---|---|---|---|
| (A) HLA | |||||
| Class I alleles | |||||
| A21 | 0.0002 | 2.22 | 101/258 (39.1%) | 75/265 (28.3%) | 10.8 |
| A22 | 0.001 | 3.02 | 30/70 (42.8%) | 54/200 (27.0%) | 15.8 |
| G 14 bp(+/+)3 | 0.01 | 2.70 | 19/74 (25.7%) | 3/39 (7.7%) | 18.0 |
| Class II alleles | |||||
| DR44 | 0.003 | 3.24 | 10/32 (31.3%) | 117/950 (12.3%) | 19.0 |
| DR45 | 0.004 | 1.60 | 50/205 (24.4%) | 68089/406503(16.8%) | 7.6 |
| SE6 | <0.001 | 19.80 | 17/50 (34.0%) | 2/79 (2.5%) | 31.5 |
| Class III alleles | |||||
| C4BQ06 | 0.03 | 4.60 | 27/50 (54.0%) | 16/79 (20.2%) | 13.8 |
| (B) KIR | |||||
| Kir genes | |||||
| 3DS17 | 0.004 | 1.89 | 83/158 (52.5%) | 65/176 (36.9%) | 15.6 |
| 2DS17 | 0.00007 | 2.45 | 95/158 (60.1%) | 67/176 (38.1%) | 22.0 |
| 2DS28 | 0.030 | 1.83 | 63/90 (70.0%) | 140/250 (56.0%) | 14.0 |
| aKIR*7 | 0.0004 | 1.36 | 126/158 (79.7%) | 128/176 (72.7%) | 7.0 |
| Kir haplotypes | |||||
| cA019 | 0.00001 | 0.53 | 110/178 (61.8%) | 6248/9024 (69.2%) | −7.4 (protective) |
| cB019 | 0.005 | 1.69 | 41/178 (23.0%) | 1184/9024 (13.1%) | 9.9 |
| cB01/tA019 | 0.002 | 2.06 | 25/170 (14.7%) | 697/9024 (7.7%) | 7.0 |
| Kir genes + HLA ligands | |||||
| aKIR + HLA7 | 0.0006 | 1.56 | 117/155 (75.5%) | 104/164 (63.4%) | 12.1 |