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. 2016 Apr 12;2(1):1–20. doi: 10.1007/s41048-016-0021-8

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Examples of BFCs useful for radiolabeling of cyclic RGD peptides. HYNIC and MAG₂ are useful for ^99mTc-labeling while DOTA, NOTA, and their derivatives are better suited for chelation of ⁶⁴Cu and ⁶⁸Ga. For ¹⁸F-labeling, 4-FB, 4-FBz, 2-FP, and 2-FDG are often used as prosthetic groups. The Al(NOTA) chelate is highly efficient for radiosynthesis of ¹⁸F radiotracers using a kit formulation