Fig. 8.

A Comparison of organ uptake (%ID/g) for ^99mTc-2P-RGD₂ in athymic nude mice bearing U87MG glioma xenografts in the absence or presence of excess RGD₂ at 60 min p.i. Co-injection of excess RGD₂ resulted in significant reduction in the uptake of ^99mTc-2P-RGD₂ in the tumor and normal organs. B Comparison of the 60-min biodistribution data of ¹¹¹In-3P-RGD₂ and ¹¹¹In-3P-RGK₂ in athymic nude mice bearing U87MG glioma xenografts. The low tumor uptake for ¹¹¹In-3P-RGK₂ indicates that the radiolabeled cyclic RGD dimers are RGD-specific. The experimental data were adapted from Shi et al. (2011a)