Table 3.
Propensity for use of triptans in pregnancy for the main (“MoBa”) study and the external validation study (“MIMEGA”)
| MoBa Study | MIMEGA Study | |||
|---|---|---|---|---|
| Odds Ratio | 95% Confidence Interval | Odds Ratio | 95% Confidence Interval | |
| Age in years1 | 1.0 | 1.0 to 1.1 | 1.0 | 1.0 to 1.1 |
| BMI (kg/m2) | ||||
| <18.5 | 0.8 | 0.4 to 1.5 | -- | -- |
| 18.5-25 | REF | -- | -- | |
| >25 | 1.1 | 0.9 to 1.4 | -- | -- |
| Multiparous | 0.9 | 0.7 to 1.1 | 0.5 | 0.2 to 1.0 |
| Married or cohabitating | 0.6 | 0.4 to 1.0 | 0.7 | 0.2 to 2.6 |
| Mother Education | ||||
| University or higher vs. other categories | 0.8 | 0.6 to 1.0 | 1.5 | 0.8 to 2.9 |
| Smoking during pregnancy | 0.9 | 0.7 to 1.3 | 1.4 | 0.4 to 4.1 |
| Alcohol during pregnancy | 1.4 | 1.1 to 1.9 | 5.2 | 1.4 to 19.2 |
| Folate Supplementation | 1.1 | 0.9 to 1.4 | 1.3 | 0.5 to 3.4 |
| Medications Taken In Pregnancy | ||||
| Opioids | 2.9 | 2.1 to 4.1 | 3.1 | 1.4 to 6.6 |
| Acetaminophen | 1.7 | 1.3 to 2.2 | 1.9 | 0.9 to 4.0 |
| NSAIDs | 2.1 | 1.6 to 2.7 | 4.9 | 2.2 to 11.1 |
| Anticonvulsants | 0.9 | 0.1 to 6.6 | -- | -- |
| Antidepressants | 1.1 | 0.5 to 2.6 | -- | -- |
| Benzodiazepines | 2.6 | 1.0 to 6.9 | -- | -- |
| Medications Before Pregnancy | ||||
| Triptans | 21.4 | 16.1 to 28.5 | 27.9 | 3.8 to 204.9 |
| Opioids | 1.5 | 1.0 to 2.3 | 1.2 | 0.6 to 2.6 |
| Acetaminophen | 1.0 | 0.8 to 1.3 | 1.5 | 0.8 to 3.1 |
| NSAIDs | 0.9 | 0.7 to 1.2 | 1.1 | 0.6 to 2.1 |
| Anticonvulsants | 1.9 | 0.4 to 8.4 | -- | -- |
| Antidepressants | 1.3 | 0.8 to 2.1 | -- | -- |
| Benzodiazepines | 1.6 | 0.7 to 3.8 | -- | -- |
| Maternal Depression | 1.0 | 0.7 to 1.4 | 2.2 | 0.7 to 6.9 |
| Migraine Type | ||||
| With Aura vs Other/Don’t know | -- | -- | 1.1 | 0.5 to 2.6 |
| Without Aura vs Other/Don’t know | -- | -- | 1.8 | 0.8 to 4.1 |
| Migraine Severity Score (MIGSEV) 1 | -- | -- | 1.2 | 1.1 to 1.4 |
| Beliefs About Medicines Questionnaire (BMQ): Necessity Subscale 1 | -- | -- | 1.2 | 1.1 to 1.3 |
| Beliefs About Medicines Questionnaire (BMQ): Concern Subscale 1 | -- | -- | 1.1 | 1.0 to 1.2 |
1
Odds of triptan use in pregnancy associated with a one-unit increase in age, MIGSEV score or BMQ score