Table 4.
Comparison of associations between prenatal triptan exposure and neurodevelopmental outcome observed with multivariable adjusted, propensity adjusted, and propensity matched models
| β1 | 95% Confidence Interval | |
|---|---|---|
|
| ||
| Emotionality, Activity, and Shyness Questionnaire (EAS) | ||
| EAS Sociability | ||
| Unadjusted (MoBa study only) | 0.04 | -0.07 to 0.15 |
| Multivariable-adjusted (MoBa study only)2 | 0.02 | -0.10 to 0.14 |
| PS-adjusted (MoBa study only)3 | 0.02 | -0.10 to 0.14 |
| PS-matched (MoBa study only)4 | 0.02 | -0.11 to 0.15 |
| EAS Emotionality | ||
| Unadjusted (MoBa study only) | -0.02 | -0.14 to 0.10 |
| Multivariable-adjusted (MoBa study only)2 | 0.00 | -0.13 to 0.13 |
| PS-adjusted (MoBa study only)3 | -0.01 | -0.14 to 0.12 |
| PS-matched (MoBa study only)4 | -0.04 | -0.18 to 0.09 |
| EAS Activity | ||
| Unadjusted (MoBa study only) | 0.06 | -0.06 to 0.17 |
| Multivariable-adjusted (MoBa study only)2 | 0.03 | -0.09 to 0.16 |
| PS-adjusted (MoBa study only)3 | 0.03 | -0.09 to 0.16 |
| PS-matched (MoBa study only)4 | 0.05 | -0.09 to 0.18 |
| EAS Shyness | ||
| Unadjusted (MoBa study only) | 0.08 | -0.04 to 0.19 |
| Multivariable-adjusted (MoBa study only)2 | 0.05 | -0.07 to 0.18 |
| PS-adjusted (MoBa study only)3 | 0.05 | -0.07 to 0.18 |
| PS-matched (MoBa study only)4 | 0.09 | -0.04 to 0.22 |
|
| ||
| Ages and Stages Questionnaire (ASQ) | Odds Ratio1 | 95% Confidence Interval |
|
| ||
| ASQ Gross Motor | ||
| Unadjusted (MoBa study only) | 0.44 | 0.16 to 1.20 |
| Multivariable-adjusted (MoBa study only)2 | 0.42 | 0.15 to 1.18 |
| PS-adjusted (MoBa study only)3 | 0.46 | 0.16 to 1.31 |
| PS-matched (MoBa study only)4 | 0.54 | 0.18 to 1.61 |
| ASQ Fine Motor | ||
| Unadjusted (MoBa study only) | 1.37 | 1.06 to 1.77 |
| Multivariable-adjusted (MoBa study only)2 | 1.29 | 0.97 to 1.72 |
| PS-adjusted (MoBa study only)3 | 1.29 | 0.97 to 1.73 |
| PS-matched (MoBa study only)4 | 1.29 | 0.94 to 1.76 |
| ASQ Communication | ||
| Unadjusted (MoBa study only) | 1.22 | 0.52 to 2.88 |
| Multivariable-adjusted (MoBa study only)2 | 0.96 | 0.37 to 2.46 |
| PS-adjusted (MoBa study only)3 | 1.02 | 0.41 to 2.53 |
| PS-matched (MoBa study only)4 | 0.78 | 0.28 to 2.14 |
β is the change in standard deviation units associated with triptan exposure during fetal development, compared to no triptan exposure; Odds Ratio is the odds of not yet having acquired one or more skill in each domain associated with triptan exposure, relative to no exposure.
Adjusted for maternal age, pre-pregnancy BMI, reproductive history, marital status, maternal education, smoking or alcohol use during pregnancy, presence of depressive symptoms, pre-pregnancy triptan use, and co-medication use during pregnancy (acetaminophen, opioids, NSAIDs, antidepressants)
Adjusted for the propensity for taking triptans during pregnancy, conditional on maternal age, pre-pregnancy BMI, reproductive history, marital status, maternal education, smoking or alcohol use during pregnancy, presence of depressive symptoms, pre-pregnancy triptan use, and co-medication use during pregnancy (acetaminophen, opioids, NSAIDs, antidepressants)
Each exposed triptan user was matched to two non-users based on propensity score; models were further adjusted for factors that remained unbalanced after matching (pregnancy use of opioids and NSAIDs)