Table 5.
Sensitivity analysis: propensity calibration to adjust for migraine type, severity, and medication beliefs
| β | 95% Confidence Interval | Percent Change3 from Main PS-adjusted to PSC-adjusted models | |
|---|---|---|---|
|
| |||
| Emotionality, Activity, and Shyness Questionnaire (EAS) | |||
| EAS Sociability | |||
| PS-adjusted (MoBa study only)1 | 0.02 | -0.10 to 0.14 | |
| PSC-adjusted (MoBa and Internet Migraine studies)2 | 0.01 | -0.13 to 0.14 | -50.0% |
| EAS Emotionality | |||
| PS-adjusted (MoBa study only)1 | -0.01 | -0.14 to 0.12 | |
| PSC-adjusted (MoBa and Internet Migraine studies)2 | -0.01 | -0.13 to 0.11 | 0.0% |
| EAS Activity | |||
| PS-adjusted (MoBa study only)1 | 0.04 | -0.08 to 0.17 | |
| PSC-adjusted (MoBa and Internet Migraine studies)2 | 0.03 | -0.11 to 0.17 | -25.0% |
| EAS Shyness | |||
| PS-adjusted (MoBa study only)1 | 0.06 | -0.07 to 0.19 | |
| PSC-adjusted (MoBa and Internet Migraine studies)2 | 0.04 | -0.06 to 0.18 | -33.3% |
|
| |||
| Ages and Stages Questionnaire (ASQ) | OR | 95% Confidence Interval | Percent Change3 from Main PS-adjusted to PSC-adjusted models |
|
| |||
| ASQ Gross Motor | |||
| PS-adjusted (MoBa study only)1 | 0.43 | 0.15 to 1.22 | |
| PSC-adjusted (MoBa and Internet Migraine studies)2 | 0.45 | 0.14 to 1.42 | -4.7% |
| ASQ Fine Motor | |||
| PS-adjusted (MoBa study only)1 | 1.28 | 0.96 to 1.71 | |
| PSC-adjusted (MoBa and Internet Migraine studies)2 | 1.25 | 0.89 to 1.74 | -2.4% |
| ASQ Communication | |||
| PS-adjusted (MoBa study only)1 | 1.02 | 0.42 to 2.48 | |
| PSC-adjusted (MoBa and Internet Migraine studies)2 | 0.93 | 0.31 to 2.81 | 9.7% |
Adjusted for the propensity for taking triptans during pregnancy, conditional on maternal age, pre-pregnancy BMI, reproductive history, marital status, maternal education, smoking or alcohol use during pregnancy, presence of depressive symptoms, pre-pregnancy triptan use, and co-medication use during pregnancy (acetaminophen, opioids, NSAIDs, antidepressants). PS-adjusted estimates are not IPC-weighted, and so differ slightly from those reported in Table 4.
Adjusted for the propensity for taking triptans during pregnancy (estimate from Table 3) and calibrated for migraine severity, migraine type, and attitude towards medication (BMQ Necessity and Concern scores), not including BMI and antidepressant exposure [inclusion of BMI and antidepressant use in PS did not result in substantial change in β estimates]
Percent change calculated as [ (PSCadjusted − PSadjusted) / PSCadjusted ] *100