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(Left) 15,000× SEM image of a 2 mg/mL collagen gel demonstrates the ability of electron microscopy to reveal complex organization of individual collagen fibrils and fibril aggregates within a gel. (Right) 60× confocal reflection image of a 2 mg/mL collagen gel reveals the limited ability of optical microscopy to distinguish individual collagen fibrils and their complex nanoscale interactions.
