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. 2016 Oct 18;111(8):1724–1737. doi: 10.1016/j.bpj.2016.08.032

Figure 8.

Figure 8

A schematic representation of the mode of action of VG16KRKP against C. neoformans. VG16KRKP is thought to initially interact with the cell surface (conformation 1) through electrostatic interaction, followed by structural stabilization (conformation 2) and hence insertion into the membrane via transient membrane damage. It thereby gets access inside the cell and hinders the DNA-related processes eventually leading to cell death. To see this figure in color, go online.