Figure 3.

Structure and relative occupancy of symmetry-related epitopes. (A) Whole-virion structure used for binding simulations for flavivirus Abs E106 (left), 1F4 (middle), and EDE2-A1 (right), showing epitopes colored with respect to their symmetry-related epitope environment for the threefold (epitope A, green), twofold (epitope B, cyan), and fivefold (epitope C, magenta) axes of symmetry. (B) Binding curves showing Ab occupancy at epitopes A, B, and C, as well as total Ab occupancy from monovalent binding simulations of the respective Abs. To see this figure in color, go online.