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. 2016 Oct 18;111(8):1641–1654. doi: 10.1016/j.bpj.2016.09.003

Figure 5.

Figure 5

Modeling bivalent binding of IgG antibodies to flavivirus. (A) Neutralization curves from monovalent and bivalent binding simulations for Abs E106, EDE2-A11, and E16. Experimental data for Fab and MAb neutralization for E106 was derived from (45). (B) Molecular models of bivalent binding for IgG Abs E106, EDE2-A11, and E16. Epitopes A (threefold axis), B (twofold axis), and C (fivefold axis) on the flavivirus envelope are colored green, cyan, and magenta, respectively. Fabs are noted with a red dotted circle. To see this figure in color, go online.