Table 2.

Maximum Ab Occupancy

Name	${\mathit{r}}_{\text{Fab}}$ (Å)	Cryo-EM				Simulated
		Total	A	B	C	Total	A	B	C	Kdapp (μM)	IC50 (nM)
		(N)				(N)
Ideal	–	–	–	–	–	180	60	60	60	1.0	25
2D22	25.0	180	60	60	60	176	59	59	59	0.4	20
EDE1-C8	27.8	–	–	–	–	141	59	51	31	1.3	25
D1-E106	27.8	–	–	–	–	132	60	60	12	0.4	25
EDE2-A11	27.8	180	60	60	60	131	51	29	51	1.0	25
E16	27.8	120	60	60	0	130	59	59	12	0.8	25
14c10	27.8	120	0	60	60	120	13	47	60	0.5	25
1F4	27.8	120	0	60	60	120	17	43	60	0.5	25
5J7	32.0	60	–	–	60	59	0	13	46	0.7	63
5H2	27.8	–	–	–	–	107	15	43	48	0.5	25