. 2016 Mar 31;37(9):1170–1186. doi: 10.1002/elps.201500530

Table 3.

Overview of EME hyphenated to CE. EF and ER values indicated in italic are calculated based on data provided in the paper

Ref.	Tech.	Hyph.	Det.	Matrix	Compounds*	LOD	EF	ER	V_donor	V_acceptor	ET	ST	EV
						(nM)		(%)	(mL)	(μL)	(min)	(min)	(V)
50	EME	online	UV	Urine	loperamide, methadone, haloperidol, nortryptiline, pethidine	0.41‐60	25‐196	0.10‐0.79	0.2	0.008	2	25	200
48	EME	offline	UV	Urine	drugs and amino acids^**	2.1‐2500	0.35‐39	0.20‐21.7	3.5	20	5	4	±4/±40
[69]	EME	offline	UV		S‐and R‐propranolol				4	20	32	19	40
				Urine		27	132‐134	66‐67
				Plasma		39	108‐110	54‐55
[70]	EME	offline	UV						4	20	20	7	125
				Hair	methadone, ephedrine, methamphetamine	9.8‐41	116‐140	56‐64
				Urine	methadone, methamphetamine, ephedrine	4.9‐18	112‐128	58‐70
[71]	EME	offline	UV	Urine	thebaine, ibuprofen	23‐24	150‐160	75‐80	4	20	25	10	40
52	EME	offline	UV						4	20	10	14	5
				Acedemic	naproxen, ibuprofen	4.3‐7.3	180‐188	90‐94
				Plasma		n.r.	138‐154	69‐77
				Waste water		n.r.	180‐184	90‐92
				Breast milk		n.r.	148‐156	74‐78
				Urine		n.r.	170‐176	85‐88
51	EME	offline	UV	Urine	buprenorfine	2.1	185	92	4	20	15	10	200
[72]	EME	offline	UV						4	20	15	20	15
				Academic	naproxen, diclofenac	6.56‐8.17	176‐184	88‐92
				Urine	diclofenac, naproxen	15.3‐15.8	164–176	82–88
				Plasma	diclofenac, naproxen	19.7‐20.5	158–166	79–83
[73]	EME	offline	UV and C⁴D	Environmental water	chlorinated phenoxyacetic acids***	≤19‐≤39	6.8‐11	15‐25	0.9	20	5	10	150
49	EME	offline	C⁴D	Saliva	spermine, spermidine, cadaverine, putrescine	8.4‐79	17 ‐ 106	1.9‐12	7	8	20	22	10
[74]	EME	offline	C⁴D	Plasma	3,4‐methylenedioxy‐metamphetamine, amphetamine, metamphetamine	5.2‐17	97‐103	65‐69	3	20	10	7	300
40	EME	offline	C⁴D						10	100	10	5.3	1500
				Academic	glyphosphate, aminomethylphosphonic acid	0.25‐0.58	87‐95	86‐96
				River water		n.r.	85‐95	85‐95

¹matrix is only mentioned when extraction performance is tested therein.

*in order of increasing LOD.

**loperamide, haloperidol, nortriptyline, tryptophan, phenylalanine, creatinine, tyrosine, histidine, arginine.

***pentachlorophenol, 2,4,6‐trichlorophenol, 2,3‐dichlorophenol, 2,3‐dichlorophenol, 2‐chlorophenol, 3‐chlorophenol, 4‐chlorophenol.

****3,4‐methylenedioxy‐methamphetamine, amphetamine, methamphetamine.

#loperamide, methadone, nortriptyline, pethidine, haloperidol.