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. 2016 Oct 20;6:35749. doi: 10.1038/srep35749

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Copyright © 2016, The Author(s)

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(Ai) Raw trace of fictive swimming showing an entire 2 hour experiment. The application of 100 μM bupropion clearly inhibited swimming after approximately 20 minutes. (Aii) A comparison of the effect onset in a bupropion experiment and a dopamine experiment. (B) Raw traces showing 500 ms of activity at the start of an evoked episode in control, 100 μM bupropion, and following drug washout. (C) Bupropion (100 μM) significantly reduced episode duration (i: p < 0.01, n = 13) and the number of spontaneous episodes of swimming (ii: p < 0.05, n = 4). (D) Bupropion (100 μM) also significantly reduced swim frequency (i: p < 0.001. n = 13) and burst durations (ii: p < 0.05. n = 5).