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. 2016 Oct 20;6:35749. doi: 10.1038/srep35749

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Copyright © 2016, The Author(s)

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(Ai) Raw trace of fictive swimming showing an entire experiment. The application of 10 μM L745,870 has a clear excitatory effect on swimming. (Aii) Raw traces showing ~500 ms of activity at the start of an evoked episode in control, 10 μM L745,870, and following drug washout. B: L745,870 (10 μM) significantly increased episode duration (i: p < 0.01, n = 8) and the number of spontaneous episodes of swimming (ii: p < 0.01, n = 7). C. L745,870 (10 μM) also significantly reduced swim frequency (i: p < 0.01. n = 8) but had no significant effect on burst durations (ii: p > 0.05. n = 7).