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. 2016 Oct 20;6:35749. doi: 10.1038/srep35749

Figure 8. The activation of D2 receptors modifies the integrative electrical properties of spinal CPG neurons.

Figure 8

(A) An example of the cellular response to depolarising current pulses in control, in 50 μM DA and following washout of dopamine. (Bi) Pooled data showing that dopamine significantly increases rheobase (p < 0.01, n = 5). (Bii) The effect persists when the RMP of the cell is corrected to control value using DC current injection (p < 0.01, n = 5). (Biii) F-I plot for the cell shown in A. Dopamine shifted the FI curve to the right, demonstrating reduced firing frequency in response to the same current input. (C) Responses to depolarising current pulses in control, in 25 μM quinpirole and following washout of quinpirole. (Di) Pooled data showing that quinpirole also significantly increases rheobase (p < 0.05, n = 9), which persisted when the RMP was corrected (Dii, p < 0.05, n = 5). (Diii) F-I plot for the cell shown in (C). Quinpirole shifted the FI curve to the right, demonstrating reduced firing frequency in response to the same current input.