Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Oct 18;7:13132. doi: 10.1038/ncomms13132

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(a) Schematic depicting use of E-Fibs to improve impaired conduction in an in vitro model of cardiac interstitial fibrosis. (b) Immunostaining corresponding to dashed-line square area in a showing vimentin⁺ E-HDFs in between sarcomeric α-actinin (SAA)⁺ neonatal rat cardiomyocytes (CMs). (c–e) Average CV (c), APD₈₀ (d) and impulse wavelength (WL=CVxAPD₈₀, e) values during longitudinal or transverse conduction in CM-only cultures (fibrosis control), CM+wt-HDF co-cultures, CM+Na_vSheP D60A/Kir2.1-expressing HDF co-cultures, CM+Cx43-expressing HDF co-cultures, CM+E-HDF co-cultures and confluent anisotropic CM cultures (healthy control) (n=5–8). *P<0.001 versus transverse CVs in fibrosis control group. Error bars indicate s.e.m; statistical significance was determined by one-way analysis of variance, followed by Tukey's post-hoc test to calculate P-values.