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. 2016 Oct 20;6:35512. doi: 10.1038/srep35512

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Copyright © 2016, The Author(s)

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(a) Analysis of cell proliferation (CCK-8 assay) on the surface of the PPTi and NPTi after incubation with BMSCs for 1, 4 and 7 days (n = 4). A significant difference in cell proliferation was observed between the PPTi and NPTi at 4 days and 7 days, suggesting that the PPTi exhibits good biocompatibility and an improved cell proliferation ability. *p < 0.05, **p < 0.01 compared to the NPTi. (b) Osteogenic differentiation of BMSCs on the PPTi and NPTi as indicated by ALP activity after 7, 14 and21 days of culture in osteogenic media. Osteogenic cell differentiation was significantly greater on the PPTi at 21 days compared with the NPTi (*p < 0.05).