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. 2016 Oct 20;6:35475. doi: 10.1038/srep35475

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Copyright © 2016, The Author(s)

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(a) Puerarin at the concentrations of 10 μM, 100 μM, 1 mM and10 mM significantly inhibited Kv7.1 currents illustrated by the protocol of voltage steps, respectively. (b) I-V curves summarized inhibitory effects of puerarin at concentrations of 10 μM, 100 μM, 1 mM, 10 mM and recovery after compound wash off. Different concentrations of puerarin decreased the Kv7.1 from (24.3 ± 1.1) pA/pF to (19.1 ± 1.0) pA/pF, (7.9 ± 0.8) pA/pF, (6.1 ± 0.4) pA/pF, (4.8 ± 0.8) pA/pF, and decreased the Kv7.1-tail current from (10.4 ± 0.6) pA/pF to (8.8 ± 0.7) pA/pF, (3.8 ± 0.6) pA/pF, (2.5 ± 0.9) pA/pF, (2.0 ± 0.5) pA/pF at 40 mV, respectively. (c) Concentration dependent inhibition by puerarin upon Kv7.1 at the peak currents and tail currents. Dosage curve was fitted with non-linear Hill. IC₅₀ = 36.01 μM at the peak currents and IC₅₀ = 39.77 μM at the tail currents, Hill coefficient is 0.997. n = 6 each point.