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. 2016 Oct 20;6:35270. doi: 10.1038/srep35270

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Comparison of the contact frequency distribution between co-mutation pairs and overall background and gene-level background contact frequencies. All pairwise co-mutated contact frequency (Pairwise comut.) distributions were significantly higher than the overall background (Overall bkg.) values and the gene-level background (Gene-level bkg.) values, with all P-values < 10⁻⁹⁹. (a) The three contact frequency distribution violin plots of the 12 TCGA cancers, based on IMR90 Hi-C data. (b) The three contact frequency distribution violin plots of the 12 TCGA cancers, based on hESC Hi-C data. (c) The overall background contact frequency decay function over the bin-level linear distance on IMR90 chromosome 1. (d) The overall background and gene-level background contact frequency decay scatter plots over the bin-level linear distance on hESC chromosome 1. Comparison of the contact frequency distribution between co-mutation pairs and overall background contact frequency and gene-level background contact frequency within single cells from two patients with prostate cancer based on IMR90 (e) and hESC Hi-C data (f).