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. 2016 Oct 20;6:35270. doi: 10.1038/srep35270

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Comparison of intra- and inter-class contact frequency distributions. (a) The results of the 12 TCGA cancers, based on IMR90 Hi-C data. The left part (purple) of each violin plot is the intra-class contact frequency distribution. The right part (sky blue) of each violin plot is the inter-class contact frequency distribution (b) The results of the 12 TCGA cancers, based on hESC Hi-C data. (c) The original heatmaps of each chromosome were grouped based on the IMR90 Hi-C dataset and were then diagonally normalised for each chromosome (d). (e) The Pearson correlation coefficient (PCC) matrices were taken on the diagonal-normalised Hi-C heatmaps. (f–h) The zoomed-in matrices on chromosome 2 are shown as an example. We further overlapped these matrices with the co-mutated genes identified by TCGA/COSMIC datasets in sample matrices.