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. 2016 Oct 20;6:35270. doi: 10.1038/srep35270

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) The proportions of KEGG signalling pathway enrichment among different gene clusters from the 12 TCGA databases (DB), IMR90 Hi-C data and SCHs (overlap) were statistically compared, with different significance cut-offs. The average KEGG pathways represented (b) and the percentages of cancer driver genes (c) among the three datasets were also statistically compared for the 12 TCGA cancer types.