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. 2016 Oct 18;7:13223. doi: 10.1038/ncomms13223

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Copyright © 2016, The Author(s)

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(a) The unusually large ES42L (blue) binds srRNA2 (red) and a C-terminal extension of eL28 (yellow and cyan) in L. donovani. eL28 rests in a groove which lies between two RNA helices in ES42L. The L. donovani unique portion of the extension is coloured cyan, superimposed against that in T. brucei³ (magenta). (b,c) Boxed regions of (a) showing interactions between the C-terminal extension of eL28 and ES42L. (d) A closeup, 180° rotated view of the boxed region in (a), showing the kissing helix interaction between srRNA2 and ES42L formed by canonical basepairing. (e) Positioning of eS17 in L. donovani and T. brucei in relation to the trypanosome unique portions of ES6S and ES7S. Dashed line depicts flexible region of ES7S visible in the cryoEM map.