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. 2016 Oct 20;6:35788. doi: 10.1038/srep35788

Figure 5. Metformin enhanced the chemotherapeutic efficacy of cisplatin in vivo.

Figure 5

(A) The images of HSC3 xenograft mice treated with PBS control, cisplatin (10 mg/kg), metformin (10 mg/kg), and cisplatin + metformin for 21 days, ten days after tumourigenesis are represented. (B) The tumour images of HSC3 xenograft mice mentioned in (A) were evaluated. (C) The growth curves of PBS control, cisplatin (10 mg/kg), metformin (10 mg/kg), and cisplatin + metformin treated HSC3 xenograft tumours. (D) The tumour weight of each group was analysed. (*p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001).