Figure 8. Formaldehyde alters the activity of heterologous human αβγ-ENaC channels expressed in oocytes.

Oocytes were continuously perfused with formaldehyde and amiloride, and whole cell currents were monitored at 10-s intervals. (A) Representative inward current traces in the presence of formaldehyde and amiloride. Currents were digitized at −120 mV. Application of drugs is indicated by solid horizontal lines. (B) Average currents at −120 mV (mean ± SE). **P < 0.01 compared with basal level. N = 10 from 4 different frogs.