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. 2016 Oct 20;6:35631. doi: 10.1038/srep35631

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Copyright © 2016, The Author(s)

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(A) CXCL7 and CXCL9 were detected the PPIs with receptors of CXCR family (CXCRn-N_ubG) using growth assay, and the result showed different PPIs intensity with each receptors, in which obvious PPIs were detected between CXCL7 and CXCR2 and between CXCL9 and CXCR3. (B) Interleukin ligand/receptor pairs, IL1A/IL1R1 and IL6/IL6RA, were detected the interactions. CXCL12 and CXCR4 was used as negative controls of bait and prey respectively, and Ost1-N_ubI was used as positive prey control. Through growth assays, the expected interactions of IL1A/IL1R1 and IL6/IL6RA were detected correctly, meanwhile, no crosstalk was detected between unmatched ligand/receptor pairs.