Table 7.
Significant GO or other functional terms downregulated by 9500 treatment
| Category | Term | Count | % | Fold Enrichment | Raw p value | Bonferroni corrected p value |
|---|---|---|---|---|---|---|
| SP_PIR_KEYWORDS | phosphoprotein | 208 | 57.14 | 1.60 | 1.07E-17 | 3.75E-15 |
| SP_PIR_KEYWORDS | actin-binding | 23 | 6.32 | 5.19 | 7.04E-10 | 2.48E-07 |
| GOTERM_BP_FAT | GO:0016125~sterol metabolic process | 17 | 4.67 | 8.19 | 2.08E-10 | 3.91E-07 |
| SP_PIR_KEYWORDS | Steroid biosynthesis | 11 | 3.02 | 15.33 | 1.55E-09 | 5.44E-07 |
| SP_PIR_KEYWORDS | lipid synthesis | 15 | 4.12 | 8.53 | 2.21E-09 | 7.79E-07 |
| GOTERM_BP_FAT | GO:0008203~cholesterol metabolic process | 16 | 4.40 | 8.46 | 5.10E-10 | 9.58E-07 |
| GOTERM_MF_FAT | GO:0003779~actin binding | 27 | 7.42 | 4.04 | 2.88E-09 | 1.58E-06 |
| GOTERM_BP_FAT | GO:0016126~sterol biosynthetic process | 11 | 3.02 | 15.29 | 1.29E-09 | 2.42E-06 |
| SP_PIR_KEYWORDS | sterol biosynthesis | 9 | 2.47 | 20.07 | 8.01E-09 | 2.82E-06 |
| SP_PIR_KEYWORDS | Cholesterol biosynthesis | 8 | 2.20 | 23.48 | 2.31E-08 | 8.12E-06 |
| GOTERM_CC_FAT | GO:0005912~adherens junction | 17 | 4.67 | 5.72 | 4.28E-08 | 1.34E-05 |
| GOTERM_BP_FAT | GO:0007010~cytoskeleton organization | 30 | 8.24 | 3.35 | 2.32E-08 | 4.36E-05 |
| GOTERM_CC_FAT | GO:0070161~anchoring junction | 17 | 4.67 | 5.16 | 1.84E-07 | 5.77E-05 |
| GOTERM_CC_FAT | GO:0005856~cytoskeleton | 55 | 15.11 | 2.08 | 1.87E-07 | 5.88E-05 |
| GOTERM_BP_FAT | GO:0006695~cholesterol biosynthetic process | 9 | 2.47 | 16.84 | 3.17E-08 | 5.96E-05 |
| GOTERM_CC_FAT | GO:0015629~actin cytoskeleton | 21 | 5.77 | 4.07 | 2.19E-07 | 6.87E-05 |
| GOTERM_MF_FAT | GO:0008092~cytoskeletal protein binding | 31 | 8.52 | 3.00 | 1.40E-07 | 7.63E-05 |
| GOTERM_CC_FAT | GO:0042641~actomyosin | 8 | 2.20 | 15.46 | 5.43E-07 | 1.71E-04 |
| GOTERM_BP_FAT | GO:0030029~actin filament-based process | 21 | 5.77 | 4.24 | 1.17E-07 | 2.20E-04 |
| GOTERM_BP_FAT | GO:0008202~steroid metabolic process | 19 | 5.22 | 4.58 | 1.77E-07 | 3.32E-04 |
| GOTERM_BP_FAT | GO:0030036~actin cytoskeleton organization | 20 | 5.49 | 4.31 | 2.00E-07 | 3.76E-04 |
| GOTERM_BP_FAT | GO:0007167~enzyme linked receptor protein signaling pathway | 24 | 6.59 | 3.41 | 5.84E-07 | 1.10E-03 |
| GOTERM_MF_FAT | GO:0016717~oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water | 5 | 1.37 | 40.67 | 2.46E-06 | 1.35E-03 |
| KEGG_PATHWAY | hsa00900:Terpenoid backbone biosynthesis | 6 | 1.65 | 17.53 | 1.36E-05 | 1.44E-03 |
| GOTERM_CC_FAT | GO:0001725~stress fiber | 7 | 1.92 | 15.22 | 4.59E-06 | 1.44E-03 |
| SP_PIR_KEYWORDS | cytoskeleton | 30 | 8.24 | 2.63 | 4.23E-06 | 1.49E-03 |
| SP_PIR_KEYWORDS | actin binding | 8 | 2.20 | 11.15 | 6.18E-06 | 2.17E-03 |
| GOTERM_CC_FAT | GO:0032432~actin filament bundle | 7 | 1.92 | 14.05 | 7.60E-06 | 2.39E-03 |
| SP_PIR_KEYWORDS | cytoplasm | 93 | 25.55 | 1.56 | 6.98E-06 | 2.45E-03 |
| KEGG_PATHWAY | hsa00100:Steroid biosynthesis | 6 | 1.65 | 15.47 | 2.70E-05 | 2.86E-03 |
| GOTERM_CC_FAT | GO:0016323~basolateral plasma membrane | 15 | 4.12 | 3.86 | 3.50E-05 | 1.09E-02 |
| SP_PIR_KEYWORDS | disease mutation | 52 | 14.29 | 1.82 | 3.28E-05 | 1.15E-02 |
| GOTERM_CC_FAT | GO:0005913~cell-cell adherens junction | 7 | 1.92 | 10.43 | 4.64E-05 | 1.45E-02 |
| UP_SEQ_FEATURE | short sequence motif:Histidine box-2 | 5 | 1.37 | 30.87 | 1.20E-05 | 1.57E-02 |
| UP_SEQ_FEATURE | short sequence motif:Histidine box-3 | 5 | 1.37 | 30.87 | 1.20E-05 | 1.57E-02 |
| UP_SEQ_FEATURE | short sequence motif:Histidine box-1 | 5 | 1.37 | 30.87 | 1.20E-05 | 1.57E-02 |
| GOTERM_BP_FAT | GO:0006694~steroid biosynthetic process | 11 | 3.02 | 6.30 | 8.91E-06 | 1.66E-02 |
| GOTERM_CC_FAT | GO:0030054~cell junction | 25 | 6.87 | 2.52 | 5.48E-05 | 1.71E-02 |
| GOTERM_CC_FAT | GO:0030055~cell-substrate junction | 11 | 3.02 | 5.12 | 5.50E-05 | 1.71E-02 |
| SP_PIR_KEYWORDS | acetylation | 74 | 20.33 | 1.57 | 7.54E-05 | 2.62E-02 |
| KEGG_PATHWAY | hsa04520:Adherens junction | 9 | 2.47 | 5.12 | 3.07E-04 | 3.21E-02 |
| GOTERM_CC_FAT | GO:0005925~focal adhesion | 10 | 2.75 | 5.11 | 1.42E-04 | 4.36E-02 |
Note: Terms italicized are those that are shared between different treatments or mentioned in Result and Discussion.