Fig. 7.

Effect of compound 1 on cell surface levels of CD11b, CD14 and CCR2 on untreated (“unstim”) and IL-1β-treated (“IL-1β”) monocytes. Monocytes from whole blood were incubated for 72 hours with or without IL-1β (10 ng/mL), in the presence or absence of compound 1. Samples were analyzed using flow cytometry. Graphs show (A) the MFI of CD14+ cells displaying CD11b, (B) the MFI of CD14 cell surface levels, and (C) the MFI of CCR2 cell surface levels. Data are expressed as mean ± SEM (n = 4–9). *P < 0.01 compared to IL-1β-stimulated groups.