Table 1.
Conservation of function between described transcription factors in A. fumigatus, C. neoformans and Candida spp. and their correspondent homologs predicted by the Phylome DB.
| Function | Transcription factor | Similar function (homologs) | Distinct function (homologs) | Unknown function (homologs) | Similar function (non-homologs) |
|---|---|---|---|---|---|
| Drug resistance (efflux pumps expression) | Pdr1 (C. glabrata) | N.A. | N.A. | N.A. | Tac1 (C. albicans) |
| Mrr1 (C. albicans) | |||||
| Mrr2 (C. albicans) | |||||
| Stb5 (C. glabrata) | Stb5 (C. albicans) | N.A. | CPAR2_109760; CTRG_04421* | N.A. | |
| Tac1 (C. albicans) | N.A. | Znc1 (C. albicans) | CPAR2_303510; CPAR2_303520 | Pdr1 (C. glabrata) | |
| CPAR2_303500; CTRG_05307 | Mrr1 (C. albicans) | ||||
| Hal9 (C. albicans) | CTRG_05306; CTRG_05308 | Mrr2 (C. albicans) | |||
| Mrr1 (C. albicans) | Mrr1 (C. parapsilosis) | Cta4 (C. albicans) | orf19.5133; orf19.7371 | Pdr1 (C. glabrata) | |
| CPAR2_501570; CPAR2_405260 CPAR2_405270; CPAR2_704130 | Tac1 (C. albicans) Mrr2 (C. albicans) | ||||
| CPAR2_807260; CTRG_02269* | |||||
| CTRG_02696*; CTRG_02712* | |||||
| CTRG_02268*; CTRG_05208* | |||||
| CTRG_00538*; CTRG_02271* | |||||
| CPAR2_501570; CPAR2_405260 CPAR2_405270; CPAR2_704130 | |||||
| Mrr2 (C. albicans) | Mrr1 (C. parapsilosis) | Cta4 (C. albicans) | CPAR2_405270; CPAR2_807820 | Pdr1 (C. glabrata) | |
| CAGL0M12298g; CTRG_05568* | Tac1 (C. albicans) | ||||
| Mrr1 (C. albicans) | |||||
| Drug resistance (ergosterol biosynthesis) | Upc2 (C. albicans) | Upc2 (C. parapsilosis) | N.A. | Ecm22 (C. albicans) | N.A. |
| Upc2a (C. glabrata)* | Upc2 (C. tropicalis)* | ||||
| Upc2b (C. glabrata)* | |||||
| SrbA (A. fumigatus) | SrbB (A. fumigatus) | N.A. | N.A. | Sre1 (C. neoformans) | |
| Virulence (hyphal growth/biofilm formation) | Efg1 (C. albicans) | Efg1 (C. parapsilosis) | StuA (A. fumigatus) | CAGL0L01771g | N.A. |
| StuA (A. fumigatus) | |||||
| Efh1 (C. albicans) | CTRG_01780 | ||||
| Efh1 (C. albicans) | Efg1 (C. albicans) | N.A. | Efh1 (C. parapsilosis); CTRG_01780 | StuA (A. fumigatus) | |
| Cph1 (C. albicans) | Ste12 (C. glabrata) | N.A. | Cph1 (C. parapsilosis) | N.A. | |
| Cph1 (C. tropicalis)* | |||||
| Ste12 (C. glabrata) | Cph1 (C. albicans) | N.A. | CAGL0H02145g; SteA (A. fumigatus) | N.A. | |
| Tec1 (C. albicans) | N.A. | N.A. | CPAR2_805930 | AbaA (A. fumigatus) | |
| Bcr1 (C. albicans) | Bcr1 (C. parapsilosis) | N.A. | CTRG_00608 | N.A. | |
| Cst6 (C. glabrata) | N.A. | N.A. | N.A. | Rca1 (C. albicans) | |
| Rca1 (C. albicans) | N.A. | N.A. | CPAR2_109540; CTRG_04281* | N.A. | |
| SomA (A. fumigatus) | N.A. | N.A. | N.A. | N.A. | |
| BrlA (A. fumigatus) | N.A. | N.A. | N.A. | N.A. | |
| MedA (A. fumigatus) | CNAG_03859* | N.A. | |||
| Znf2 (C. neoformans) | Csr1 (C. albicans) | ZafA (A. fumigatus) | N.A. | N.A. | |
| Nrg1 (C. albicans) | Nrg1 (C. tropicalis) | N.A. | CPAR2_300790; CTRG_00608 | N.A. | |
| CAGL0G08107g | |||||
| Csr1 (C. albicans) | N.A. | N.A. | CPAR2_403080; CTRG_03883 | N.A. | |
| CAGL0J05060g | |||||
| Rfg1 (C. albicans) | N.A. | N.A. | CPAR2_801100 | N.A. | |
| Ace2 (C. glabrata) | Swi5 (C. glabrata) | N.A. | N.A. | Ace2 (C. albicans) | |
| Ace2 (A. fumigatus) | |||||
| Ace2 (C. albicans) | Ace2 (C. parapsilosis) | N.A. | CTRG_03073* | Ace2 (C. glabrata) | |
| Ace2 (A. fumigatus) | |||||
| Virulence (nitrogen use) | Gat1 (C. albicans) | N.A. | N.A. | Gat1; CTRG_03831* | AreA (A. fumigatus) |
| Virulence (pH and weak acid response) | Rim101 (C. albicans) | N.A. | N.A. | CPAR2_700450 | PacC (A. fumigatus) |
| Rim101 (C. tropicalis)* | |||||
| War1 (C. albicans) | N.A. | N.A. | CPAR2_110360; CTRG_04350 | N.A. | |
| War1 (C. glabrata) | |||||
| Afu7g01640; Afu8g00950 | |||||
| Mnl1 (C. albicans) | N.A. | N.A. | CPAR2_204380 | Msn4 (C. albicans) | |
| Msn2 (C. glabrata) | |||||
| CTRG_03074 | Msn4 (C. glabrata) | ||||
| SebA (A. fumigatus) | |||||
| Msn4 (C. albicans) | N.A. | N.A. | CPAR2_301730 | Mnl1 (C. albicans) | |
| Msn2 (C. glabrata) | |||||
| CTRG_03253 | Msn4 (C. glabrata) | ||||
| SebA (A. fumigatus) | |||||
| Phenotypic switching | Wor1 (C. albicans) | N.A. | N.A. | CPAR2_805000; CTRG_03345 | N.A. |
| Afu6g04490 | |||||
| Wor2 (C. albicans) | N.A. | N.A. | CPAR2_405400 | N.A. | |
| Czf1 (C. albicans) | N.A. | N.A. | CTRG_03771 | N.A. | |
| Wor3 (C. albicans) | N.A. | N.A. | CPAR2_202450; CTRG_00711 | N.A. | |
| Wor4 (C. albicans) | N.A. | N.A. | CPAR2_808100; CTRG_05581 | N.A. | |
| Iron homeostasis | HapX (A. fumigatus) | N.A. | N.A. | N.A. | Hap43 (C. albicans) |
| Hap43 (C. albicans) | N.A. | N.A. | CPAR2_209090; CTRG_04121* | N.A. | |
| SreA (A. fumigatus) | Sfu1 (C. albicans) | N.A. | N.A. | N.A. | |
| Sfu1 (C. albicans) | N.A. | N.A. | CPAR2_700810; CTRG_03356 | N.A. | |
| Oxidative stress resistance (antioxidant gene expression) | Cap1 (C. albicans) | Yap1 (C. glabrata) | N.A. | CPAR2_405030 | Yap1 (A. fumigatus) |
| Yap1 (C. tropicalis)* | Yap1 (C. neoformans) | ||||
| Skn7 (C. albicans) | Skn7 (C. glabrata) | N.A. | CPAR2_304240; Skn7 (C. tropicalis)* | Skn7 (A. fumigatus) | |
| Skn7 (A. fumigatus) | Skn7 (C. albicans) | Skn7 (C. neoformans) | N.A. | Skn7 (C. glabrata) | |
| AtfA (A. fumigatus) | Atf1 (C. neoformans) | Atf1 (C. neoformans) | N.A. | N.A. | |
| Sko1 (C. albicans) | AtfA (A. fumigatus) | N.A. | CTRG_04352; Sko1 (C. glabrata) | N.A. | |
| Nitrosative stress resistance | Cta4 (C. albicans) | N.A. | Mnl1 (C. albicans) | N.A. | N.A. |
| Msn4 (C. albicans) | |||||
| Yap4 (C. neoformans) | N.A. | N.A. | N.A. | N.A. | |
| Amino acid starvation | Gcn4 (C. albicans) | N.A. | N.A. | Gcn4 (C. parapsilosis) | CpcA (A. fumigatus) |
| CTRG_02060; Gcn4 (C. glabrata) | |||||
| Gliotoxin production | MtfA (A. fumigatus) | N.A. | N.A. | N.A. | N.A. |
| Melanin production | Mbs1 (C. neoformans) | N.A. | Mbp1 (C. albicans) | Swi6 (C. albicans); Afu7g05620 | N.A. |
| Swi4 (C. albicans) | Afu3g13920*; CND05520 | ||||
| Cell cycle | Mbp1 (C. albicans) | N.A. | N.A. | CPAR2_102740; CAGL0D01012g | N.A. |
| CAGL0A04565g; Afu7g05620 | |||||
| Mbp1 (C. tropicalis) |
N.A., Not Available;
*
Homologs identified by BLASTp.