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. 2016 Oct 20;5:3. doi: 10.1186/s13619-016-0031-5

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Inhibition of the N-glycosylation pathway enhances hair cell regeneration. a The N-glycosylation pathway and the inhibition targets of swainsonine and 1-deoxynojirimycin (DNJ). The targets of inhibition for swainsonine and DNJ are indicated by red arrows. b Swainsonine treatment causes a transient increase in hair cell regeneration. There is a significant difference at 2 dpa between the control and 5 μg/ml swainsonine treatment, as well as between the control and 50 μg/ml of swainsonine (p < 0.001 for both). There is no difference between swainsonine at 5 and 50 μg/ml (p = 0.063). c DNJ treatment causes a transient increase in hair cell regeneration. Graphs represent data from the analysis of 10 embryos per data point. Error bars show the s.e.m. There is a significant difference at 2 dpa between the control and 250 μM of DNJ (p = 0.014)