Fig. 4.

Distribution of the basin size for the phenotype attractors in the attractor landscape before and after performing reverse control and the essentiality of control nodes for each accumulation stage of driver mutations. a and c The results of reverse control for transforming the cellular state to a quiescent or normal proliferative phenotype. a Reverse control to a quiescent phenotype (green color). c Reverse control to a normal proliferative phenotype (blue color). We should reshape the attractor landscape at each accumulation stage of driver mutations to make all initial states of attractor landscape converge to the attractor of a quiescent or a normal proliferative phenotype by regulating the activity of control nodes. In the right panel, colored boxes represent the classified attractors that indicate different cellular phenotypes. More details about the attractor classification are described in the main text. b and d Essentiality of control nodes identified in the reverse control. b Essentiality of control nodes for a quiescent phenotype. d Essentiality of control nodes for a normal proliferative phenotype. The essentiality indicates the capability of each control node to change the original attractor landscape into the desired one