Table 1.
The minimal sets of control nodes for the reverse control
| APC mutation |
APC + KRAS mutations |
APC + KRAS + PTEN mutations |
APC + KRAS + PTEN + TP53 mutations |
Control direction |
|---|---|---|---|---|
| Control nodes for a quiescent phenotype | ||||
| beta-catenin | beta-catenin | beta-catenin | beta-catenin |
|
| P115RhoGEF | P115RhoGEF | P115RhoGEF | P115RhoGEF |
|
| MEK | MEK | MEK | MEK |
|
| PP2A | PP2A | PP2A | PP2A |
|
| Control nodes for a normal proliferative phenotype | ||||
| beta-arrestin | beta-arrestin | beta-arrestin | beta-arrestin |
|
| Erk | Erk | Erk | Erk |
|
| P115RhoGEF | P115RhoGEF | P115RhoGEF | P115RhoGEF |
|
| Smad2/4 | Smad2/4 | Smad2/4 | Smad2/4 |
|
| Snail |
|
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