Table 3.
Changes in response to mixed meals following weight loss in the placebo and liraglutide groups
| Variable | Placebo (n = 25) | Liraglutide (n = 24) |
p value for liraglutide vs placebo |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | 14 weeks | Mean changea | p value | Baseline | 14 weeks | Mean changea | p value | ||
| Fasting glucose, mmol/l | 6.0 (5.5–6.3) | 5.7 (5.6–6.2) | 0.1 (−3, 3) | 0.85 | 5.9 (5.3–6.2) | 5.3 (5.1–5.6) | −8.8 (−12, −6) | <0.001 | <0.001 |
| Fasting insulin, pmol/l | 118 (85–161) | 97 (88–139) | −3.8 (−17, 9) | 0.14 | 101 (78–137) | 83 (70–124) | −4.6 (−18, 8) | 0.17 | 0.97 |
| Glucose AUC, mmol/l × 8 h | 51.6 (48.3–53.4) | 51.5 (48.3–53.1) | −0.1 (−3, 2) | 0.78 | 50.2 (47.6–54.1) | 46.4 (44.0–48.8) | −8.2 (−11, −6) | <0.001 | <0.001 |
| Insulin AUC, pmol/l × 8 h | 3,028 (2,139–5,056) | 3,111 (2,465–4,111) | −1.1 (−12, 10) | 0.18 | 2,660 (1,910–3,799) | 2,715 (1,500–3,319) | −7.9 (−22, 7) | 0.03 | 0.46 |
| NEFA AUC, mmol/l × 8 h | 2,657 (2,286–3,086) | 2,490 (2,138–2,989) | −2.1 (−10, 6) | 0.15 | 2,563 (2,086–3,137) | 2,360 (1,589–2,846) | −14 (−20, −8) | <0.001 | 0.03 |
Data are medians (interquartile range) unless stated otherwise
a
Mean change relative to baseline, % (95% CI)