Table 1.
Demographics and healthcare utilization of women diagnosed with breast cancer by antidepressant drugs (mutually exclusive groups)
| Characteristics * | Paroxetine (SSRI) | Fluoxetine (SSRI) | Other SSRI | Tricyclics (amitriptyline, nortriptyline, imipramine, doxepin, desipramine) | Other types (venlafaxine, trazodone, buprion, tetracyclics) | Multiple types (SSRIs and other antidepressants) | Nonusers | Total+ |
|---|---|---|---|---|---|---|---|---|
| No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | |
| Age at first diagnosis, y | ||||||||
| <40 | 15 (3.1) | 42 (4.1) | 9 (3.3) | 25 (2.2) | 34 (2.7) | 120 (3.1) | 400 (4.6) | 645 (3.8) |
| 40–49 | 85 (17.7) | 200 (19.4) | 52 (19.2) | 146 (12.6) | 263 (20.9) | 748 (19.2) | 1779 (20.2) | 3273 (19.4) |
| 50–59 | 126 (26.2) | 268 (26.0) | 71 (26.2) | 275 (23.7) | 424 (33.7) | 1114 (28.6) | 2257 (25.7) | 4535 (26.9) |
| 60–69 | 130 (27.0) | 271 (26.3) | 61 (22.5) | 375 (32.2) | 302 (24.0) | 1035 (26.6) | 2234 (25.4) | 4408 (26.1) |
| 70–79 | 92 (19.1) | 183 (17.7) | 56 (20.7) | 285 (24.5) | 173 (13.7) | 672 (17.3) | 1629 (18.5) | 3090 (18.3) |
| 80+ | 33 (6.9) | 68 (6.6) | 22 (8.1) | 57 (4.9) | 63 (5.0) | 203 (5.2) | 490 (5.6) | 936 (5.5) |
| Year of diagnosis | ||||||||
| 1996–1998 | 207 (43.0) | 288 (27.9) | 73 (26.9) | 461 (39.6) | 341 (27.1) | 1371 (35.2) | 2952 (33.6) | 5693 (33.7) |
| 1999–2001 | 116 (24.1) | 218 (21.1) | 44 (16.2) | 267 (23.0) | 293 (23.3) | 926 (23.8) | 1706 (19.4) | 3570 (21.1) |
| 2002–2005 | 125 (26.0) | 416 (40.3) | 92 (34.0) | 327 (28.1) | 445 (35.4) | 1259 (32.4) | 2805 (31.9) | 5469 (32.4) |
| 2006–2007 | 33 (6.9) | 110 (10.7) | 62 (22.9) | 108 (9.3) | 180 (14.3) | 336 (8.6) | 1326 (15.1) | 2155 (12.8) |
| Race/ethnicity | ||||||||
| Non-Hispanic white | 372 (77.3) | 810 (78.5) | 212 (78.2) | 851 (73.2) | 984 (78.2) | 3140 (80.7) | 5835 (66.4) | 12 204 (72.3) |
| Hispanic | 53 (11.0) | 103 (10.0) | 30 (11.1) | 94 (8.1) | 94 (7.5) | 307 (7.9) | 758 (8.6) | 1439 (8.5) |
| African American | 29 (6.0) | 56 (5.4) | 12 (4.4) | 105 (9.0) | 100 (7.9) | 252 (6.5) | 815 (9.3) | 1369 (8.1) |
| Asian/Pacific Islander | 26 (5.4) | 58 (5.6) | 15 (5.5) | 111 (9.5) | 76 (6.0) | 179 (4.6) | 1332 (15.2) | 1797 (10.6) |
| Other/unknown | 1 (0.2) | 5 (0.5) | 2 (0.7) | 2 (0.2) | 5 (0.4) | 14 (0.4) | 49 (0.6) | 78 (0.5) |
| Geocoded median household income$, † | ||||||||
| Q1 (Lower 25%) <41 793 | 134 (28.6) | 256 (25.6) | 54 (20.9) | 311 (27.5) | 253 (20.7) | 959 (25.2) | 2134 (25.1) | 4101 (25.0) |
| Q2 (>25% - 50%) >41 793 - 56 442 | 114 (24.3) | 272 (27.2) | 61 (23.6) | 270 (23.9) | 294 (24.1) | 977 (25.6) | 2106 (24.8) | 4094 (25.0) |
| Q3 (>50% - 75%) >56 442 - 74 659 | 122 (26.0) | 246 (24.6) | 71 (27.5) | 267 (23.6) | 327 (26.8) | 952 (25.0) | 2113 (24.9) | 4098 (25.0) |
| Q4 (Top 25%) >74 659 | 99 (21.1) | 226 (22.6) | 72 (27.9) | 283 (25.0) | 347 (28.4) | 925 (24.3) | 2144 (25.2) | 4096 (25.0) |
| Utilization, No. of outpatient visits up to 1 y before diagnosis | ||||||||
| None | 1 (0.2) | 4 (0.4) | 1 (0.4) | 3 (0.3) | 6 (0.5) | 5 (0.1) | 43 (0.5) | 63 (0.4) |
| Q1 (1 - 14) | 106 (22.0) | 219 (21.2) | 52 (19.2) | 213 (18.3) | 289 (23.0) | 576 (14.8) | 2945 (33.5) | 4400 (26.1) |
| Q2 (15 - 26) | 107 (22.3) | 262 (25.4) | 63 (23.3) | 261 (22.4) | 331 (26.3) | 810 (20.8) | 2350 (26.7) | 4184 (24.8) |
| Q3 (27 - 45) | 141 (29.3) | 267 (25.9) | 78 (28.8) | 321 (27.6) | 323 (25.7) | 1050 (27.0) | 1978 (22.5) | 4158 (24.6) |
| Q4 (46+) | 126 (26.2) | 280 (27.1) | 77 (28.4) | 365 (31.4) | 310 (24.6) | 1451 (37.3) | 1473 (16.8) | 4082 (24.2) |
| Mean no. of visits | 37.0 | 37.2 | 38.7 | 39.5 | 35.2 | 46.4 | 28.5 | |
| Median no. of visits | 37.0 | 28.5 | 29.0 | 31.0 | 27.0 | 35.0 | 21.0 | |
| Utilization, No. of hospitalizations up to 1 y before diagnosis | ||||||||
| 0 | 359 (74.6) | 819 (79.4) | 219 (80.8) | 909 (78.2) | 999 (79.4) | 2895 (74.4) | 7230 (82.3) | 13 430 (79.5) |
| 1+ | 122 (25.4) | 213 (20.6) | 52 (19.2) | 254 (21.8) | 260 (20.7) | 997 (25.6) | 1559 (17.7) | 3457 (20.5) |
| Charlson Index (year prior to breast cancer diagnosis) | ||||||||
| 0 | 300 (62.4) | 673 (65.2) | 182 (67.2) | 670 (57.6) | 803 (63.8) | 2299 (59.1) | 6037 (68.7) | 10 964 (64.9) |
| 1 or 2 | 150 (31.2) | 299 (29.0) | 80 (29.5) | 412 (35.4) | 393 (31.2) | 1315 (33.8) | 2391 (27.2) | 5040 (29.9) |
| 3 or more | 31 (6.4) | 60 (5.8) | 9 (3.3) | 81 (7.0) | 63 (5.0) | 278 (7.1) | 361 (4.1) | 883 (5.2) |
* P values for all variables were <.01. Probabilities based on chi-square test for homogeneity. All statistical tests were two-sided. SSRI = selective serotonin reuptake inhibitor.
† N does not add to total because of missing data.