Table 3.
Adjusted HRs for subsequent breast cancer risk by percent overlap* of antidepressant and tamoxifen use by duration of tamoxifen therapy
| Tamoxifen duration |
Paroxetine | Fluoxetine | Other SSRIs | Tricyclics | Other types | |
|---|---|---|---|---|---|---|
| % overlap | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | |
| 1 y | 0.25 | 1.06 (0.98 to 1.14) | 1.00 (0.95 to 1.07) | 0.98 (0.90 to 1.07) | 1.01 (0.95 to 1.09) | 1.08 (0.98 to 1.19) |
| 0.50 | 1.13 (0.98 to 1.30) | 1.01 (0.91 to 1.14) | 0.97 (0.81 to 1.16) | 1.04 (0.91 to 1.19) | 1.17 (0.96 to 1.43) | |
| 0.75 | 1.20 (0.97 to 1.49) | 1.03 (0.86 to 1.22) | 0.95 (0.72 to 1.25) | 1.06 (0.87 to 1.29) | 1.26 (0.94 to 1.70) | |
| 2 y | 0.25 | 1.03 (0.96 to 1.10) | 0.99 (0.94 to 1.05) | 1.00 (0.93 to 1.09) | 1.03 (0.97 to 1.09) | 1.10 (0.96 to 1.27) |
| 0.50 | 1.07 (0.94 to 1.21) | 0.98 (0.89 to 1.09) | 1.00 (0.86 to 1.18) | 1.06 (0.95 to 1.19) | 1.21 (0.93 to 1.60) | |
| 0.75 | 1.10 (0.91 to 1.33) | 0.98 (0.84 to 1.14) | 1.01 (0.79 to 1.29) | 1.09 (0.92 to 1.29) | 1.34 (0.89 to 2.03) | |
| 3 y | 0.25 | 1.01 (0.92 to 1.09) | 0.97 (0.92 to 1.04) | 1.02 (0.93 to 1.13) | 1.04 (0.97 to 1.11) | 1.13 (0.94 to 1.35) |
| 0.50 | 1.00 (0.86 to 1.18) | 0.95 (0.84 to 1.08) | 1.05 (0.86 to 1.28) | 1.08 (0.94 to 1.24) | 1.27 (0.88 to 1.83) | |
| 0.75 | 1.00 (0.79 to 1.28) | 0.93 (0.77 to 1.13) | 1.07 (0.80 to 1.45) | 1.12 (0.91 to 1.38) | 1.42 (0.83 to 2.47) | |
| 4 y | 0.25 | 0.97 (0.87 to 1.09) | 0.96 (0.87 to 1.05) | 1.04 (0.91 to 1.20) | 1.05 (0.96 to 1.15) | 1.25 (0.91 to 1.44) |
| 0.50 | 0.95 (0.75 to 1.18) | 0.92 (0.77 to 1.10) | 1.09 (0.83 to 1.44) | 1.10 (0.92 to 1.32) | 1.32 (0.83 to 2.09) | |
| 0.75 | 0.92 (0.66 to 1.29) | 0.89 (0.68 to 1.16) | 1.14 (0.76 to 1.72) | 1.16 (0.88 to 1.53) | 1.51 (0.76 to 3.03) | |
| 5 y | 0.25 | 0.94 (0.81 to 1.10) | 0.94 (0.81 to 1.06) | 1.07 (0.89 to 1.28) | 1.06 (0.94 to 1.20) | 1.17 (0.88 to 1.55) |
| 0.50 | 0.89 (0.66 to 1.20) | 0.89 (0.71 to 1.13) | 1.14 (0.79 to 1.64) | 1.13 (0.88 to 1.44) | 1.37 (0.78 to 2.40) | |
| 0.75 | 0.85 (0.54 to 1.32) | 0.84 (0.59 to 1.21) | 1.21 (0.70 to 2.09) | 1.19 (0.83 to 1.73) | 1.61 (0.69 to 3.74) |
* Percent age of days of overlap of antidepressant and tamoxifen use were modeled as continuous variables. CI = confidence interval; HR = hazard ratio; SSRI = selective serotonin reuptake inhibitor.