Table 2.
List of the eight candidate genes ordered by the expression in the GWAT microarray selected as potential new targets.
| Gene name | Gene symbol | Microarray (Fold change) | Meta-analysis | ||
|---|---|---|---|---|---|
| AortaA Ldlr-/- (HFSC) versus Ldlr-/- (CD) | GWAT WT (HFD) versus WT (CD) | Cardiovascular disease pVal | Type 2 diabetes pVal | ||
| Macrophage metalloelastase | MMP12/Mmp12 | 11.2 | 16.9 | 0.00232 | 0.00077 |
| Triggering receptor expressed on myeloid cells 2 | TREM2/Trem2 | 2.5 | 13.3 | 0.00067 | 0.01094 |
| Macrophage-expressed gene 1 protein | MPEG1/Mpeg1 | 4.4 | 7.8 | 0.00097 | 0.00018 |
| G protein-coupled receptor 137B | GPR137B/Gpr137b | 2.0 | 5.7 | 0.03752 | 0.00298 |
| Spleen tyrosine kinase | SYK/Syk | 1.5 | 3.0 | 0.01389 | 0.00163 |
| v-mafmusculoaponeurotic fibrosarcoma oncogene family, protein B | MAFB/Mafb | - | 2.7 | 0.00034 | 0.04552 |
| Phospholipid transfer protein | PLTP/Pltp | 1.4 | 2.3 | 0.04339 | 0.00107 |
| Ribonucleoside-diphosphate reductase subunit M2 | RRM2/Rrm2 | - | 1.8 | 0.04549 | 0.00726 |
A
The aorta microarray experiment was not considered for gene selection, as no differentially expressed genes with an adjusted p < 0.05 was found.