Figure 18.

YD0171 inhibits tumor growth and metastasis formation in nude mice subjected to intracecal HCT116 cell implantation. Mice were subjected to intracecal implantation of HCT116 cells. On posttumor injection d 3, mice were randomized into subcutaneous treatment with either vehicle, YD0171 (1 mg/kg) or oxaliplatin (5 mg/kg), each 5 d/wk. On posttumor injection d 51, the cecum, liver, lung and lymph nodes were harvested, and primary tumor size (cecum) and metastasis (liver, lung and lymph nodes) were quantified using a weighted score. Right side panels show representative photomicrographs and histological pictures of (A) the primary tumor and (B) the liver metastasis; human tumor tissue is highlighted by the brown staining. Data represent mean ± SEM values of n = 6–8 animals per group; *p < 0.05 and **p < 0.01 indicate a significant inhibitory effect of YD0171 compared with vehicle control.