Table 2.

Metabolomic effects: modulation of selected cellular energetics-related metabolites in HCT116 cells by YD0171 and AOAA treatment (1 mmol/L, 24 h). Numbers represent fold changes in metabolite concentrations; red background indicates an increase, green background indicates a decrease in the concentration of the metabolite over vehicle-treated control.

	AOAA	YD0171
TCA cycle, oxidative phosphorylation
Citrate	1.52	1.95
Isocitrate	1.66	3.02
α-Ketoglutarate	2.04	3.13
Succinylcarnitine	0.38	0.38
Succinate	0.42	0.56
Fumarate	0.12	0.19
Malate	0.12	0.27
2-Methylcitrate/homocitrate	1.39	1.19
Acetylphosphate	1.49	1.53
Phosphate	1.13	1.07
Glycolysis, gluconeogenesis, pyruvate metabolism
Glucose	1.82	1.47
Glucose 6-phosphate	1.53	1.55
Fructose-6-phosphate	0.64	0.69
Isobar: fructose 1,6-diphosphate, glucose 1,6-diphosphate, myo-inositol 1,4 or 1,3-diphosphate	2.56	2.06
2,3-Diphosphoglycerate	0.84	0.62
Dihydroxyacetone phosphate	1.87	0.86
3-Phosphoglycerate	1.89	2.36
Phosphoenolpyruvate	3.07	3.31
Pyruvate	4.91	3.83
Lactate	0.53	0.62
Glycerate	1.07	0.85
Pentose phosphate pathway
6-Phosphogluconate	1.55	1.66
Ribose 1-phosphate	0.38	0.31
5-Phosphoribosyl diphosphate	3.42	1.22
Sedoheptulose-7-phosphate	1.77	2.08
Creatine metabolism
Creatine	1.13	1.19
Creatinine	0.81	0.88
Creatine phosphate	1.59	1.86