Table 3.

Metabolomic effects of AOAA and YD0171: enrichment analysis. Clusters with >5 measured metabolites are presented. Concordance is calculated as the % of metabolites affected by AOAA that are also affected by YD0171 for clusters where more metabolites were affected by AOAA than YD0171 and concordance is calculated as the % of metabolites affected by YD0171 that are also affected by AOAA for clusters where more metabolites were affected by YD0171 than AOAA.

Pathway cluster	Metabolites measured in cluster	Metabolites affected by AOAA (%)	Metabolites affected by YD0171 (%)	Concordance of the metabolites (%)
TCA cycle	8	7 (88)	7 (88)	100
Polyamine metabolism	7	6 (86)	4 (57)	67
Phospholipid metabolism	43	33 (77)	23 (53)	70
Plasmalogen	10	7 (70)	5 (50)	71
Glutamate metabolism	10	6 (60)	6 (60)	100
Nicotinate and nicotinamide metabolism	10	6 (60)	7 (70)	86
Alanine and aspartate metabolism	6	4 (67)	4 (67)	100
Fatty acid metabolism	22	13 (59)	9 (41)	69
Pyrimidine metabolism	26	15 (58)	17 (65)	88
Sphingolipid metabolism	26	15 (58)	7 (27)	47
Leucine, isoleucine and valine metabolism	21	12 (57)	7 (33)	53
Purine metabolism	35	20 (57)	18 (51)	90
Nucleotide sugar	7	4 (57)	3 (42)	80
Histidine metabolism	9	5 (56)	5 (56)	100
Vitamin B6 metabolism	6	3 (50)	3 (50)	100
γ-Glutamyl amino acid	13	6 (46)	5 (38)	83
Glycolysis, gluconeogenesis and pyruvate metabolism	11	5 (45)	3 (27)	60
Glutathione metabolism	9	4 (44)	4 (44)	100
Methionine, cysteine, SAM and taurine metabolism	18	8 (44)	4 (22)	50
Pentose metabolism	7	3 (43)	2 (29)	67
Lysine metabolism	10	4 (40)	2 (20)	50
PUFA metabolism	13	5 (38)	3 (23)	60
Urea cycle	14	5 (38)	7 (50)	71
Dipeptide	18	6 (33)	6 (33)	83
Phenylalanine and tyrosine	10	3 (30)	1 (10)	33
Glycine, serine and threonine	7	2 (29)	1 (14)	50
Aminosugar metabolism	7	1 (14)	1 (14)	100
Lysolipid	26	3 (11)	2 (7)	67