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. 2016 May 16;22:361–379. doi: 10.2119/molmed.2016.00102

Table 3.

Metabolomic effects of AOAA and YD0171: enrichment analysis. Clusters with >5 measured metabolites are presented. Concordance is calculated as the % of metabolites affected by AOAA that are also affected by YD0171 for clusters where more metabolites were affected by AOAA than YD0171 and concordance is calculated as the % of metabolites affected by YD0171 that are also affected by AOAA for clusters where more metabolites were affected by YD0171 than AOAA.

Pathway cluster Metabolites measured in cluster Metabolites affected by AOAA (%) Metabolites affected by YD0171 (%) Concordance of the metabolites (%)
TCA cycle 8 7 (88) 7 (88) 100
Polyamine metabolism 7 6 (86) 4 (57) 67
Phospholipid metabolism 43 33 (77) 23 (53) 70
Plasmalogen 10 7 (70) 5 (50) 71
Glutamate metabolism 10 6 (60) 6 (60) 100
Nicotinate and nicotinamide metabolism 10 6 (60) 7 (70) 86
Alanine and aspartate metabolism 6 4 (67) 4 (67) 100
Fatty acid metabolism 22 13 (59) 9 (41) 69
Pyrimidine metabolism 26 15 (58) 17 (65) 88
Sphingolipid metabolism 26 15 (58) 7 (27) 47
Leucine, isoleucine and valine metabolism 21 12 (57) 7 (33) 53
Purine metabolism 35 20 (57) 18 (51) 90
Nucleotide sugar 7 4 (57) 3 (42) 80
Histidine metabolism 9 5 (56) 5 (56) 100
Vitamin B6 metabolism 6 3 (50) 3 (50) 100
γ-Glutamyl amino acid 13 6 (46) 5 (38) 83
Glycolysis, gluconeogenesis and pyruvate metabolism 11 5 (45) 3 (27) 60
Glutathione metabolism 9 4 (44) 4 (44) 100
Methionine, cysteine, SAM and taurine metabolism 18 8 (44) 4 (22) 50
Pentose metabolism 7 3 (43) 2 (29) 67
Lysine metabolism 10 4 (40) 2 (20) 50
PUFA metabolism 13 5 (38) 3 (23) 60
Urea cycle 14 5 (38) 7 (50) 71
Dipeptide 18 6 (33) 6 (33) 83
Phenylalanine and tyrosine 10 3 (30) 1 (10) 33
Glycine, serine and threonine 7 2 (29) 1 (14) 50
Aminosugar metabolism 7 1 (14) 1 (14) 100
Lysolipid 26 3 (11) 2 (7) 67